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. 2020 Feb 2;9(1):1722023. doi: 10.1080/2162402X.2020.1722023

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Clustering of patients with severe irAEs based on peripheral blood T-cell parameters.

(A) Unsupervised hierarchical clustering using three T-cell parameters (Th17/Th1_pre, Ki-67_post, and eTreg_post/pre) in 13 patients with severe irAEs (1 patient/row). The z-scores are column normalized. (B) Th17/Th1_pre in the Th17-related subgroup (n = 3) and all patients other than the Th17-related subgroup (n = 88), (C) Ki-67_post in the CD8-related subgroup (n = 3) and all patients other than the CD8-related subgroup (n = 88), and (D) eTreg_post/pre in the Treg-related subgroup (n = 3) and all patients other than the Treg-related subgroup (n = 88). (E) The percentage of TNF-α⁺ cells among CD4⁺ (CD4TNF_post) or (F) CD8⁺ (CD8TNF_post) T cells in the NOS subgroup (n = 4) and all patients other than the NOS subgroup (n = 87). (G) Unsupervised hierarchical clustering using five T-cell parameters (eTreg_post/pre, Th17/Th1_pre, Ki-67_post, CD4TNF_post, and CD8TNF_post) in the 13 patients with severe irAEs (1 patient/row). The z-scores are column normalized. Error bars indicate standard deviation of the mean. Statistical analyses were performed using Mann–Whitney U test (B-F). *P < .05, ***P < .001.