Table 4. N-of-1 randomized control trial data from [23].

Patient	Consecutive pairs of mean “active vs placebo” differences in 7-item questionnaire	Mean†	SD	Serial r	Usual P	Serial P
9	0.05/-0.22/0.57/0.36	0.19	0.35	0.24	‡0.10	0.25
18	0.64/1.08/-0.36/0.79/-0.64/1.50	0.50	0.83	-0.49	0.10	0.02
23	1.22/1.07/-0.08/0.50	0.68	0.59	0.38	‡0.06	0.17
17	-0.08/0.86/1.07/1.15	0.75	0.57	0.41	0.04	0.15
15	0.86/1.43/0.65/1.86	1.20	0.55	-0.42	0.01	<0.01
12	4.29/3.15/0.78/4.49	3.18	1.70	-0.07	0.02	0.01

† Positive means indicate an improvement while taking amitriptyline. The table values in columns 1, 2, and 6 were reproduced from Table 1 on pg 449 of [23].

‡ Based on the data, the usual paired t-test returns one-sided p-values of 0.18 for Patient 9 and 0.05 for Patient 23.