Fig. 3.

Metabolomics data for the di-, tri- and tetra-peptides originating from Plasmodium falciparum (3D7)-infected red blood cells following treatment with JPC-3210, AQm, ATQ, CQ, DHA, LF, MQ, PYN, TQ, and DMSO. A, Heat map of all di-, tri- and tetra peptides detected (y axis) from all compounds (1 μm for 1 h) expressed as the mean fold change versus DMSO control from at least three biological replicates. Yellow indicates no change, while red and blue indicates increased and decreased abundances respectively. Peptides colored blue in the DMSO control were not detected in those samples. B, Hemoglobin α (Hb α) and β (Hb β) chain sequences. Blue bars indicate the peptides that could be mapped to the hemoglobin sequence, which were significantly depleted (p value < 0.05) following JPC-3210 treatment compared with the DMSO control.