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. 2019 Dec 13;19(2):308–325. doi: 10.1074/mcp.RA119.001797

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© 2020 Birrell et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 4. — Peptidomics analysis of Plasmodium falciparum (3D7) parasites treated with JPC-3210, CQ, MQ, DHA and DMSO control. A, Sequence coverage and relative abundance of endogenous peptides originating from hemoglobin α (Hb α) and hemoglobin β (Hb β). Peptide abundances are the average fold change following 5 h of drug treatment, expressed relative to the untreated control (DMSO) from at least three biological replicates. Bars represent significant changes in peptide abundance relative to the untreated control (p value < 0.05). B, Mirror chromatograms from all detected Hb α and β peptides; JPC-3210 treated versus DMSO, MQ treated versus DMSO, DHA treated versus DMSO, and CQ treated versus DMSO. The chromatograms demonstrate an overall decrease in hemoglobin derived peptides in JPC-3210, MQ, and DHA treated (top panel) compared with control, while for CQ treated (top panel), the chromatogram demonstrated an overall increase in hemoglobin derived peptides compared with control.