Fig. 1.

Radiosensitivity and protein expression changes in the IR-selected pancreatic cancer cells. A, The clonogenic cell survival assay showing that the IR-selected MIA PaCa-2-R cells are strongly radioresistant. Values are the mean ± S.E. of three independent experiments. *p, < 0.05; ***, p < 0.001. B and C, Scatter plots showing the distribution of identified soluble proteins (B) and membrane proteins (C) according to fold change and signal intensity. The significantly up-regulated proteins and down-regulated proteins (p < 0.05 in the Significance B score and log₂ fold change > 1.5) are in red and blue, respectively.