Table I. Activated and inhibited upstream regulators in the radioresistant cells relative to parental cells. The activation states were predicted by Upstream Regulator Analysis in IPA.
| Molecule type | Upstream regulator | Activation state | Activation z-score | p value of overlap |
|---|---|---|---|---|
| Growth factor & kinase | PDGF-BB | Activated | 2.21 | 2.97E-06 |
| ERBB2 | Activated | 2.41 | 2.82E-06 | |
| ERK | Activated | 2.12 | 4.97E-04 | |
| AKT1 | Activated | 2.18 | 1.39E-01 | |
| Cytokine | OSM | Activated | 2.71 | 1.29E-02 |
| IL10 | Activated | 2.04 | 2.64E-01 | |
| CSF3 | Activated | 2.00 | 2.57E-02 | |
| IL1A | Activated | 2.20 | 6.39E-02 | |
| IL15 | Activated | 2.06 | 8.28E-03 | |
| Transcription factor | STAT3 | Activated | 2.21 | 9.83E-02 |
| TCF7L2 | Activated | 2.06 | 3.81E-01 | |
| HSF2 | Inhibited | -2.00 | 4.38E-04 | |
| TP63 | Activated | 2.57 | 3.12E-04 | |
| Estrogen receptor | Inhibited | -2.98 | 9.37E-05 | |
| microRNA | Let-7 | Inhibited | -2.23 | 4.11E-02 |
| miR-122 | Inhibited | -2.23 | 1.62E-03 | |
| Others | CG | Activated | 2.04 | 5.59E-02 |
| FN1 | Activated | 2.54 | 6.91E-07 |