Table 2.

Relationship between intra-individual mean, trend, and variability in total cholesterol with primary outcomes and secondary outcomes.

Primary Outcomes	Incident CBI (N=1098)		Worsening WMG (N=1351)
	RR (95% CI)	P value	RR (95% CI)	P value
Mean	0.999 (0.995, 1.004)	0.736	0.998 (0.995, 1.000)	0.075
Trend	1.012 (0.992, 1.032)	0.256	1.009 (0.996, 1.021)	0.166
Variability	1.003 (0.989, 1.018)	0.661	1.004 (0.993, 1.014)	0.509
Secondary Outcomes	Number of CBI (N=1604)		WMG (N=1602)
	β (95% CI)	P value	β (95% CI)	P value
Mean	0.001 (−0.001, 0.003)	0.263	−0.001 (−0.004, 0.001)	0.373
Trend	−0.003 (−0.011, 0.005)	0.439	0.005 (−0.006, 0.016)	0.391
Variability	0.009 (0.003, 0.016)	0.004	0.009 (−0.0002, 0.019)	0.055

For primary outcomes, relative risks (RR) and 95% confidence intervals (CI) were estimated from RR regression models. For secondary outcomes, beta coefficients (β) and 95% CI were estimated from linear regression models. Models adjusted for age, sex, race, body mass index, hypertension, diabetes, history of tobacco use, myocardial infarction, congestive heart failure, atrial fibrillation, and TC mean and trend. Time between MRI scans was adjusted for in primary analyses.

MRI = magnetic resonance imaging, CBI = covert brain infarction, WMG = white matter grade.