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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Pharmacotherapy. 2019 Aug 13;39(9):899–911. doi: 10.1002/phar.2312

Figure 1.

Figure 1.

Medication combinations that can increase the risk of central nervous system depression and levels of each drug interaction. The levels of interaction are defined as follows: major (red) = the interaction may be life-threatening and/or require medical intervention to minimize or prevent serious adverse effects); moderate (orange) = the interaction may result in exacerbation of the patient’s condition and/or require an alteration in therapy; minor (blue) = the interaction would have limited clinical effects, and manifestations may include an increase in the frequency or severity of the side effects but generally would not require a major alteration in therapy; and no interaction found (green) according to the Micromedex online drug reference database [20].