Figure 8.

Binding of H. pylori wild-type and isogenic homB-knockout mutant strains to mucins, glycoconjugates, and DNA. Binding of H. pylori wild-type (WT) strains isolated from children with non-ulcer dyspepsia (NUD, n = 2) or with peptic ulcer disease (PUD, n = 5) and their isogenic homB-knockout (KO) mutant strains to mucins isolated from human tumor (A), human normal (B) and monkey normal (C) gastric tissue, to Le^b (D), LNT (E), and SLe^x (F) glycoconjugates, and to DNA (G). Results are expressed as the median with interquartile range, after subtraction of the background signal (no mucin) at each pH. Mann-Whitney U test comparing the binding of the WT strain vs their respective isogenic homB KO strain, * p ≤ 0.05.