Figure 1. Metabolic control of heart development and adult heart repair in the zebrafish.

(A) Trabeculae form in the heart when compact cardiomyocytes delaminate from the myocardium. Fukuda et al. found that Nrg1/ErbB2 signaling activates glycolysis to initiate the complex cell movements involved in delamination. (B) In the regenerating adult zebrafish heart, cardiomyocytes in the 'border zone' at the edge of the injured area de-differentiate and proliferate. Honkoop et al. uncovered a role for Nrg1/ErbB2 signaling in the control of metabolic reprogramming of the border zone cardiomyocytes from oxidative phosphorylation (OXPHOS) to glycolysis. Further, they found that glycolysis is required for proliferation after injury.