Fig. 5.

Intratumoral heterogeneity in ccRCC and co-occurrence of subtypes. (a) Tumor heterogeneity (represented as the number of patterns identified in a tumor) and tumor size. Each sample is represented by multiple dots based on the composition of the patterns it contained, and the size of the dot represents the proportion of the tumor with that pattern. The length of the whiskers are the maximum and minimum observation before 1.5 times the IQR above the 75th percentile or below the 25th percentile, respectively. (b) Heat map analysis of the morphologic subtypes and conditional positive agreement analysis. This table is not symmetric; hence, it matters which direction one searches for the same pair. For example, of tumors that developed a large nest pattern, 45% also developed a trabecular/insular pattern; whereas of tumors with a thick trabecular/insular pattern, 85% also developed a large nest pattern.