Table 1.
The results of the RNA-Sequencing results of the drug treated samples (Curcumin, Rapamycin and sActRIIB-Fc). Significant genes (P-value < 0.05, t-statistics) were identified based on the comparison of the drug treated samples to the non-treated control (see methods for details) .
| PubChem CID | Drug name and drug treatment (Supplementary figure 2) | No. of genes significant genes (P-value < 0.05, t-statistics) | Normalized no. of genes compared to PKD progressiona | No. of genes found in PKD progression clusters |
|---|---|---|---|---|
| 969,516 | Curcumin | 8030 | 840 | 503 |
| 5,284,616 | Rapamycin Short | 1600 | 840 | 441 |
| 5,284,616 | Rapamycin Long | 1250 | 840 | 322 |
| NA | sActRIIB-Fc late-short treatment | 840 | 840 | 270 |
| NA | sActRIIB-Fc early-long treatment | 4200 | 840 | 365 |
a
Number is based on the lowest maximum of significant genes. This belongs to sActRIIB-Fc Late-Short treatment.