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Detailed view of the sugar-binding pocket of the Hxt36 homology model, showing the first shell amino acid side chains that interact with bound glucose (cyan) and xylose (yellow). N367 is located to the left, pointing the side chain toward the 6-OH and 6-CH2 of glucose. Most residues in this pocket are strictly conserved between Hxt36 and XylE, apart from D337 (I in XylE), A442 (G in XylE), Y446 (W in XylE), and N469 (Q in XylE). Reproduced from Nijland et al. (2014) with permission.
