TABLE 4.
MIC and MBC range. MIC/MBC50 and MIC/MBC90 values for colistin before and after combination with azidothymidine in different media/with different inoculum.
| MIC (mg/L) | MIC (mg/L) in combination with azidothymidine | Results of checkerboard titration assays based on minimum ΣFIC | |||||||
| MIC range | MIC50 | MIC90 | MIC range | MIC50 | MIC90 | Synergistic | Additive | Indifferent | |
| CAMHB/105 (n = 13) | 4–8 | 4 | 8 | 0.25–2 | 1 | 2 | 6 | 7 | 0 |
| CAMHB/106 (n = 13) | 4–16 | 8 | 16 | 0.5–8 | 4 | 8 | 2 | 11 | 0 |
| ISB/106 (n = 13) | 8–32 | 32 | 32 | 1–32 | 8 | 8 | 4 | 7 | 2 |
| AU/106 (n = 4) | 64−>64 | 64 | >64 | 4–32 | 16 | 32 | 2 | 2 | 0 |
| MBC (mg/L) | MBC (mg/L) in combination with azidothymidine | Results of checkerboard titration assays based on minimum ΣFBC | |||||||
| MBC range | MBC50 | MBC90 | MBC range | MBC50 | MBC90 | Synergistic | Additive | Indifferent | |
| CAMHB/105 (n = 13) | 4–16 | 16 | 16 | 0.25–8 | 2 | 4 | 9 | 4 | 0 |
| CAMHB/106 (n = 13) | 4–64 | 32 | 64 | 1–8 | 4 | 8 | 7 | 5 | 1 |
| ISB/106 (n = 13) | 8–64 | 32 | 64 | 1–32 | 8 | 8 | 9 | 3 | 1 |
| AU/106 (n = 4) | 128–256 | 128 | 256 | 8–32 | 16 | 32 | 4 | 0 | 0 |