TABLE 1.

Summary of effects of donor-derived and autologous AD- and BM-MSCs and their EVs administration regimens in the Fisher-Lewis renal transplant model at the end of the study (12 weeks).

Treatment	Cell therapy	Renal function	Survival		Histology			Lymphocyte infiltration
				Tubular atrophy	Tubulitis	Capillaritis	Fibrosis
Autologous	BM-MSCL	=	↑	=	↓	↓	↓	↓ T cell and NK cells
	BM-EVL	=	=	=	↓	=	=	=
	AD-MSCL	=	↑	=	↓	↓	↓	↓ T cell and NK cells
	AD-EVL	=	=	↓	↓	↓	↓	=
Donor-derived	BM-MSCF	=	↑	↓	↓	↓	↓	=
	BM-EVF	=	=	=	↓	=	=	=
	AD-MSCF	↓	↓	Ø	Ø	Ø	Ø	Ø
	AD-EVF	=	=	↓	↓	↓	↓	↓ T cell and NK cells

=, no change; ↑, increase; ↓, decrease; Ø, no rat survives.