Table 2.
Characteristics of NMBA and control group in included studies.
| Characteristics | Gainnier, 2004 | Forel, 2006 | Papazian, 2010 | Guervilly, 2017 | Moss, 2019 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| NMBA | Control | NMBA | Control | NMBA | Control | NMBA | Control | NMBA | Control | |
| Number of patients | 28 | 28 | 18 | 18 | 177 | 162 | 13 | 11 | 501 | 505 |
| Age | 59.8 ± 17.5 | 61.5 ± 14.6 | 52.0 ± 16.0 | 61.0 ± 18.0 | 58.0 ± 16.0 | 58 ± 15.0 | 72 (63–79) | 60 (52–75) | 56.6 ± 14.7 | 55.1 ± 15.9 |
| Male sex | 21 (75) | 20 (71) | 14 (78) | 12 (67) | – | – | 9 (69) | 10 (91) | 291 (58) | 269 (53) |
| Sedation scale | Ramsay 6 | Ramsay 6 | Ramsay 6 | Ramsay 6 | Ramsay 6 | Ramsay 6 | Ramsay 6 | Ramsay 6 | Ramsay 6 | Ramsay 2-3 |
| SAPS II | 41.8 ± 10.4 | 45.4 ± 10.5 | 47.0 ± 15.0 | 49.0 ± 19.0 | 50.0 ± 16.0 | 47.0 ± 14.0 | 47 (37–54) | 48 (42–62) | – | – |
| PEEP, cmH2O | 11.1 ± 2.8 | 10.9 ± 2.4 | 13.2 ± 2.7 | 11.0 ± 2.7 | 9.2 ± 3.2 | 9.2 ± 3.5 | 11 (10-11.5) | 10 (9–12) | 12.6 ± 3.6 | 12.5 ± 3.6 |
| Plateau pressure, cmH2O | 27.1 ± 6.2 | 26.1 ± 4.0 | 27.5 ± 4.4 | 24.8 ± 5.7 | 25.0 ± 5.1 | 24.4 ± 4.7 | 23 (19–26) | 21 (19–25) | 25.5 ± 6.0 | 25.7 ± 6.1 |
| PaO2/FiO2 | 130 ± 34 | 119 ± 31 | 105 ± 22 | 125 ± 20 | 106.0± 36.0 | 115.0± 41.0 | 158 (131–185) | 150 (121–187) | 98.7 ± 27.9 | 99.5 ± 27.9 |
| FiO2, % | 70.2 ± 17.0 | 67.3 ± 15.8 | 80.0 ± 15.0 | 71.0 ± 19.0 | 79.0 ± 19.0 | 77.0 ± 22.0 | 60 (50–60) | 50 (50–70) | 80 ± 20 | 80 ± 20 |
| PaCO2, mmHg | 48.3 ± 9.0 | 47.4 ± 11.2 | 51.1 ± 9.9 | 47.2 ± 9.8 | 47.0 ± 11.0 | 47.0 ± 11.0 | 43(36-44) | 43(37-52) | – | – |
| VT, mL/kg | 7.1 ± 1.1 | 7.4 ± 1.9 | 6.5 ± 0.7 | 7.0 ± 0.7 | 6.55 ± 1.12 | 6.48 ± 0.92 | 6.2 (5.9-6.8) | 6.3 (6.0-6.9) | 6.3 ± 0.9 | 6.3 ± 0.9 |
| Days free of ventilation at day 28 | 3.7 ± 7.2 | 1.7 ± 5.3 | 6.0 ± 8.6 | 5.4 ± 6.4 | 10.6 ± 9.7 | 8.5 ± 9.4 | 7 (0–20) | 8 (0–18) | 9.6 ± 10.4 | 9.9 ± 10.9 |
| ICU mortality | 13 (46.4) | 20 (71.4) | 5 (27.8) | 10 (55.6) | 52 (29.4) | 63 (28.9) | 5 (38) | 3 (27) | – | – |
| 28 day mortality | 10 (35.7) | 17 (60.7) | – | – | 42 (23.7) | 54 (33.3) | – | – | 184 (36.7) | 187 (37.0) |
| Barotrauma | 0 | 1 (3.6) | 0 | 0 | 9 (5.1) | 19 (11.7) | – | – | 20 (4.0) | 32 (6.3) |
| ICU-acquired weakness, no./total no. (%) | 0 | 0 | 1/18 (5.6) | 1/18 (5.6) | 40/112 (35.7) | 28/89 (31.5) | – | – | 107/226 (47.3) | 89/228 (39) |
NMBA, neuromuscular blocking agents; SAPS, simplified acute physiology score; PEEP, positive end-expiratory pressure; FiO2, Fraction of inspired oxygen; VT, tidal volume; ICU, intensive care unit.