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. 2020 Jan 29;8:20. doi: 10.3389/fcell.2020.00020

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Copyright © 2020 Ding, Feng, Hu, Chen and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The features and functions of gene pairs in COME events. (A) Box plot of Pearson’s correlation coefficient between gene expression and DNA methylation for the genes involved in COME events compared with that of random genes set (p-value was calculated by independent Student’s t-test). (B,C) Enriched KEGG pathways and biological processes for the genes involved in CO and ME events (DAVID online web server). (D) Fraction of cancer genes and tumor suppressor genes (TSG) against the top N genes ranked by the degree in pan-cancer network. (E) Degree distribution of top 10 genes in pan-cancer network for each cancer and pan-cancer.