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. 2020 Jan 29;8:20. doi: 10.3389/fcell.2020.00020

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Copyright © 2020 Ding, Feng, Hu, Chen and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-occurrence and mutual exclusive events contribute to prognosis of pan-cancer. (A) Clustering heatmap based on top 15 enriched COME events in 13 clusters. The clusters are denoted by number and color in the second bar, and tissue of origin specified in the first color bar. The color in the left identified top 15 COME pairs significantly enriched in corresponding cluster. (B) Kaplan-Meier plot for the PFI of 13 clusters identified in pan-cancer. (C,D) Kaplan-Meier plot of PFI for co-methylation event of CRMP1-GRM6 and GRB7-SLC45A4 in pan-cancer, respect.