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. 2020 Jan 29;10:1632. doi: 10.3389/fphar.2019.01632

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Copyright © 2020 Kohajda, Tóth, Szlovák, Loewe, Bitay, Gazdag, Prorok, Jost, Levijoki, Pollesello, Papp, Varró and Nagy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of suppression of diastolic depolarization (DD) currents [Na+/Ca2+ exchanger (NCX) and I_f] on short time cycle length (CL) variability. When 1 µM ORM-10962 panel (A) or 3 µM ivabradine (IVA) panel (B) were applied, the variability did not change significantly. Instead, the CL was prolonged. Comparison of the effect of 1 µM ORM-10962 (ORM) (red line), 5 µM ryanodine (RYA) (blue line), and 5 µM RYA + 1 µM ORM (green line) on the CL variability shows that these compound do not change the variability significantly panel (D). In contrast IVA administration after the application of RYA+ORM caused considerably increased variability panel (E) as the Poincaré-plot (panel C, blue line) shows.