TABLE 1.

IC₅₀ values for the inhibition of neuronal activity (MSR, MBR, and MNBR) and monoamine reuptake transport (hDAT, hNET, and hSERT) of cathinones.

Neuronal activity: Following recovery, several IC₅₀ values and 95% confidence intervals could not be determined and were depicted as higher than highest concentration tested (e.g., >1000 μM). * depicts IC₅₀ values of prolonged exposure or following washout that differ significantly from acute exposure (p < 0.05). # depicts IC₅₀ values following washout that differ significantly from prolonged exposure (p < 0.05). IC₅₀ values for MBR and MNBR significantly different from MSR at the same exposure scenario (acute, prolonged, or recovery) are underlined (p < 0.05; on “>” values statistics could not be performed). IC₅₀ values for MNBR and MBR at the same exposure scenario (acute, prolonged, or recovery) did not significantly differ (p < 0.05). Transporter inhibition: * depicts hNET or hSERT IC₅₀ values significantly different from hDAT IC₅₀ values (p < 0.05). ^# depicts hSERT values significantly different from hNET IC₅₀ values (p < 0.05). Internet vs. pharmaceutical grade cathinones: ^∧ depicts IC₅₀ values from cathinones bought via the internet different from pharmaceutical grade IC₅₀ values (p < 0.05). ¹Neuronal activity data from Zwartsen et al. (2019). ²Transporter inhibition data reanalyzed from Zwartsen et al. (2017).