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. 2020 Jan 29;10:1595. doi: 10.3389/fphys.2019.01595

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Copyright © 2020 Zhou, Han, Gao, Sun, Tang, Wang, Wang and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infarct size in each groups. I/R, ischemia/reperfusion; HMGB1, high mobility group box 1 protein. LY, LY294002; IS, infarction size; IS (%) the percentage of the total section area of left ventricle occupied by the infarct. “a” vs. Sham: P < 0.01; “b” vs. I/R: P < 0.05; “c” vs. HMGB1: P < 0.01.