TABLE 1.
Comparison of variables in each groups.
| Variables | Sham | I/R | HMGB1 | LY | LY + HMGB1 |
| SOD (μ/mg) | 150.8 ± 11.26 | 75.43 ± 4.97a | 120.67± 10.35ab | 65.97 ± 3.75ac | 65.97 ± 3.75ac |
| MDA (nmol/mg) | 1.57 ± 0.26 | 9.17 ± 0.52a | 4.12 ± 0.38ab | 8.04 ± 0.41ac | 8.94 ± 0.43ac |
| LVIDs (mm) | 4.13 ± 0.78 | 5.67 ± 0.93a | 4.71 ± 0.53ab | 6.25 ± 0.57ac | 5.94 ± 0.48ac |
| LVDD (mm) | 4.04 ± 0.38 | 6.87 ± 0.78a | 5.25 ± 0.43ab | 6.93 ± 0.69ac | 6.57 ± 0.57ac |
| LVEF (%) | 70.11 ± 8.91 | 40.14 ± 3.78a | 57.89 ± 3.56ab | 38.23 ± 4.12ac | 43.67 ± 4.54ac |
| IS (%) | 0 | 47.48 ± 3.48a | 34.35 ± 5.18ab | 55.28 ± 4.71ac | 50.38 ± 3.49ac |
| CVF (%) | 1.30 ± 0.38 | 37.48 ± 4.12a | 15.15 ± 1.71ab | 34.35 ± 3.97ac | 27.43 ± 3.10ac |
I/R, ischemia/reperfusion; HMGB1, high mobility group box 1 protein; LY, LY294002; SOD, superoxide dismutase; MDA, malondialdehyde; LVIDs, left ventricular systolic diameter; LVIDd, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; IS, infarction size; CVF, collagen volume fraction. “a” vs. Sham: P < 0.05; “b” vs. I/R: P < 0.05; “c” vs. HMGB1: P < 0.05.