Table 2.
Biodistribution of [99mTc]Tc(CO)3-G3 in NMRI mice 4 h p.i. alone (control) or after administration of compounds
| Blood | Salivary glands | Liver | Spleen | GI tract | Carcass | |
|---|---|---|---|---|---|---|
| Control | 0.33 ± 0.04 | 0.7 ± 0.2 | 3.3 ± 0.3 | 0.8 ± 0.2 | 4 ± 1 | 9 ± 1 |
| Lysine | 0.28 ± 0.03 | 0.6 ± 0.1 | 3.0 ± 0.2 | 0.6 ± 0.1 | 4 ± 1 | 7 ± 1 |
| Gelofusine | 0.29 ± 0.04 | 0.7 ± 0.2 | 2.9 ± 0.4 | 0.6 ± 0.1 | 3.4 ± 0.2 | 8 ± 1 |
| Mannitol | 0.31 ± 0.04 | 0.8 ± 0.2 | 3.6 ± 0.3 | 0.8 ± 0.1 | 3.9 ± 0.3 | 9.4 ± 0.4 |
| Furosemide | 0.33 ± 0.02 | 0.9 ± 0.1 | 3.3 ± 0.3 | 0.8 ± 0.1 | 4 ± 1 | 10.1 ± 0.3 |
| Probenecid | 0.32 ± 0.06 | 0.7 ± 0.1 | 3.2 ± 0.2 | 0.9 ± 0.1 | 4 ± 1 | 8 ± 1 |
| Colchicine | 0.44 ± 0.04* | 0.5 ± 0.1 | 1.9 ± 0.3* | 1.2 ± 0.2* | 2.5 ± 0.4* | 6.9 ± 0.3 |
| Fructose | 0.8 ± 0.1* | 1.9 ± 0.4* | 7.0 ± 1.0* | 1.9 ± 0.1* | 7 ± 1* | 20 ± 2* |
| Maleate | 0.33 ± 0.05 | 0.6 ± 0.1 | 3.0 ± 0.5 | 0.7 ± 0.2 | 3.4 ± 0.2 | 9 ± 1 |
Data are presented as average from four mice ± SD, for the control—as average from eight mice ± SD. Uptake is shown in %ID/g, except for GI tract and carcass, which is shown in %ID per whole sample. An asterisk marks a significant difference between the control and the treated group (*p < 0.01, one-way ANOVA test)