Table 1.
Gadolinium content in the blood, cerebrum, cerebellum, liver, kidney, skin, and femur (mean values ± SD)
| Group (ID) | Blood (nmol/mL) | Cerebrum (nmol/g) | Cerebellum (nmol/g) | Liver (nmol/g) | Kidney (right) (nmol/g) | Skin (nmol/g) | Femur (nmol/g) |
|---|---|---|---|---|---|---|---|
| Control (A) | < LOQ | < LOQ | < LOQ | < LOQ | < LOQ | < LOQ | < LOQ |
| ProHance (B) | < LOQa | 0.144 ± 0.015b | 0.151 ± 0.039 | 0.361 ± 0.106 | 38.6 ± 25.0 | 0.400 ± 0.112 | 8.48 ± 1.87 |
| Dotarem (C) | < LOQ | 0.342 ± 0.045°°° | 0.315 ± 0.040°°° | 0.685 ± 0.330°°° | 172 ± 134°°° | 0.660 ± 0.202°°° | 6.28 ± 3.08 |
| Clariscan (D) | < LOQ | 0.377 ± 0.042°°,* | 0.345 ± 0.053°°° | 0.823 ± 0.495°°° | 212 ± 121°°° | 0.688 ± 0.215°°° | 9.44 ± 4.01 |
| Gadovist (E) | < LOQ | 0.292 ± 0.047°°°,**,### | 0.316 ± 0.040°°° | 1.22 ± 0.664°°°,**,# | 294 ± 127°°°,* | 0.999 ± 0.442°°°,**,# | 16.1 ± 4.51°°°,***,### |
n = 5 for control animals; n = 15 for all other groups except “Dotarem, skin” and “Gadovist, right kidney” where n = 14
Significance vs. group B (ProHance): °°p ≤ 0.01, °°°p ≤ 0.005; vs. group C (Dotarem): *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.005; vs. group D (Clariscan): #p ≤ 0.05, ###p ≤ 0.005
a1 out of 15 values > LOQ (0.165)
b7 out of 15 values < LOQ