Table 2.

Physico-chemical features of the gadoterate, gadobutrol, and gadoteridol molecules

	Gadoterate (Dotarem/Clariscan)	Gadobutrol (Gadovist)	Gadoteridol (ProHance)
kd (s−1)a	7.17 × 10−14	1.11 × 10− 12	1.15 × 10− 11
t½ (years)b	306,549	19,801	1911
Hydrophilic Surface (Å2)	491	404	353
Solvation enthalpy (kcal/mol)	˗36	˗12	˗9

^ak_d are the rate constants that characterize the dissociation of GBCA complexes in 0.15 M NaCl at 25 °C and pH = 7.4 [43, 44]

^bt_½ is the half-life (years) of the dissociation reactions of GBCA complexes in 0.15 M NaCl at 25 °C and pH = 7.4 (t_½ = ln2/k_d) [43, 44]