Table 2.
Chromosomes meiotic segregation in carriers of the Robertsonian (Rob) translocation der (21;22) described in literature so far
| Reference | Age | Semen concentration n × 106/mL (diagnosis) | Semen preparation | No. of cells analyzed | Segregation pattern (%) | Reproductive outcome | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Alternate normal | Alternate balanced | Alternate total | Adjacent total | Ambiguous or other | ||||||
| [13]* | 149 | 49.6 | 47 | 96.6 | 3.4 | / | ||||
| [14]** | 54 | < 20 (Oligozoospermia) | 350 | 38 | 22 | 60 | 36 | 4 | ||
| [6]** | 0.88 (Oligoasthenoteratozoospermia) | SW x3 | 1016 | 85.63 | 13.29 | 1.08 | G0P0A0 | |||
| [10]** | 29 | 31 (Normozoospermia) | SW x2 | 1000 | 76.8 | 22 | 1.2 | |||
| [15]*** | 38 | 2.9 (Oligoasthenoteratozoospermia) | SWGradient HBSS | 10010042 |
40 45 76 |
605524 | / | G0P0A0 | ||
*Studies by the hamster egg-human sperm fusion technique heterospecific fertilization
**Studies by fluorescence in situ hybridization (FISH)
***Study on the patient with double Robertsonian translocation (FISH)
SW, sperm wash; HBSS, HOST-based sperm selection; G, gestation; P, parity; A, abortion