Table 2.

CEUS LI-RADS categories

Diagnostic categories	Clinical significance	Imaging workup options
		Return to routine surveillance	Alternative diagnostic imaging (i.e., CT or MRI)	Repeat CEUS
CEUS LR-NC	Not categorizable (due to image degradation or omission)	–	≤ 3 months*	≤ 3 months**
CEUS LR-1	Definitely benign	6 months**	–	–
CEUS LR-2	Probably benign	6 months**	–	≤ 6 months*
CEUS LR-3	Intermediate probability of malignancy	–	≤ 6 months**	≤ 6 months*
CEUS LR-4	Probably HCC	Multidisciplinary discussion may be needed for consensus management. If neither biopsy nor treatment is planned: repeat or alternative diagnostic imaging in ≤ 3 months
CEUS LR-5	Definitely HCC	Diagnosis of HCC. Multidisciplinary discussion for consensus management.
CEUS LR-M	Probably or definitely malignant, not necessarily HCC	Multidisciplinary discussion for consensus management. May include alternative or repeat imaging, biopsy, or treatment
CEUS LR-TIV	Tumor in vein	Multidisciplinary discussion for consensus management. May include biopsy or biomarker correlation to determine etiology of TIV: HCC, ICC, other.

**Preferred option in most cases

*Reasonable alternative option. Not recommended