Table 2.

Multivariate analysis for covariates of the iSEND model with OS from pooled, training and independent validation cohorts

	Pooled		Training		Independent validation
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Sex: male	1.2 (0.97, 1.49)	0.0941	1.42 (0.98, 2.06)	0.0663	1.02 (0.78, 1.34)	0.8769
ECOG: 2–3	1.78 (1.36, 2.31)	<0.0001	2.05 (1.32, 3.17)	0.0013	1.75 (1.25, 2.44)	0.001
NLR ≥ 5 and DNLR ≥ 0	1.81 (1.38, 2.38)	<0.0001	3.07 (1.89, 5.0)	<0.0001	1.47 (1.06, 2.05)	0.0223

HR hazard ratio, 95% CI 95% confidence interval