Skip to main content
. 2020 Feb 4;11:684. doi: 10.1038/s41467-020-14508-5

Fig. 6. Growth kinetics of 79112 and isogenic ΔTbD1 and TbD1-complemented strains in C3HeB/FeJ mice.

Fig. 6

C3HeB/FeJ mice were aerosol infected with the Mtb 79112∆TbD1 mutant and its corresponding TbD1-intact 79112 parental and 79112∆TbD1-C complemented strains (10–15 CFU/lungs). Mtb H37Rv was included as an additional control strain. Four (a, b) and 14 (c, d) weeks after infection, the bacterial loads in lungs (a, b) and spleens (c, d) were determined. Statistical differences in CFU values obtained in organs from mice infected with different Mtb strains were determined by one-way Anova with Bonferroni post hoc test (*P < 0.05; **P < 0.01; ns: not significant). The figure reports single data points, mean and standard deviation of CFU number or CFU ratio values obtained in a representative experiment performed with 3 (a, b) or 4 (c, d) mice per group.