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. 2019 Nov 28;122(3):372–381. doi: 10.1038/s41416-019-0657-5

Fig. 2.

Fig. 2

Inhibition of CK2 and KIT signalling intermediates in GIST cell lines after treatment with the CK2 inhibitor CX4945. Immunoblot evaluations of p-CDC37, CDC37, p-KIT, KIT, p-AKT, AKT, p-MAPK, MAPK, p-S6 and S6 in GIST-T1, GIST882, GIST430/654 and GIST48 after 6 h of CX4945 treatment in serum-free medium. Actin stain is a loading control. Immunoblotting experiments were performed from two independent experiments for each cell line. Linear capture quantitation of immunoblotting chemiluminescence signals, using an ImageQuant LAS4000. Intensity values are standardised to the DMSO control.