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. 2020 Feb 4;11:696. doi: 10.1038/s41467-020-14334-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Before and b after adjusting for total brain volume. Note: Brain abnormality-by-time regression coefficients from linear mixed effects models (β) in blue refer to negative associations (slower growth in children with brain abnormality compared with children with no or mild brain abnormality) and in red refer to positive associations (faster growth in children with brain abnormality compared with children with no or mild brain abnormality), with darker coloured regression coefficients indicating stronger associations; Interaction p values are false discovery rate corrected and darker coloured p values indicate stronger significance; Boxes in the top right corner of the figures represent global brain volumes. A = anterior, P = posterior, LH = left hemisphere, RH = right hemisphere, csf = cerebrospinal fluid, gm = grey matter, wm = white matter, BSTS = banks of superior temporal sulcus, FUS = fusiform, INS = insula, PCAL = pericalcarine, PCUN = precuneus, PREC = precentral, ST = superior temporal, SMAR = supramarginal.