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. 2020 Feb 4;10:1790. doi: 10.1038/s41598-020-58599-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The volcano plot of the lung metabolomics in mice between the HMH and the PQ group (Red represents the up-regulated metabolites compared with PQ group, green represents the down-regulated metabolites compared with PQ group, and gray represents the metabolites with no difference between PQ group and HMH group. VIP value represents the importance projection value of the metabolite obtained in the PLS-DA model compared in this group. The upper figure was obtained in the negative polarity mode, and the bottom figure was obtained in the positive polarity mode).