Table 2.

The significant different metabolites between the PQ group and the control group.

No.	metabolites	VIP	ROC	P value	trend	metabolic pathway
1	Mesaconic acid	1.154	0.89	0.0055	↓	Glyoxylate and dicarboxylate metabolism;
2	L-glutamic acid	1.100	1	2.99E-05	↓	Glutathione metabolism;Alanine, aspartate and glutamate metabolism;porphyrin and chlorophyll metabolism
3	Genistein	2.587	0.89	0.0012	↓	Isoflavonoid biosynthesis
4	Lumichrome	1.481	0.99	7.82E-06	↓	Riboflavin metabolism
5	Daidzein	2.441	0.90	0.0003	↓	Isoflavonoid biosynthesis
6	3-Sulfino-L-alanine	2.658	0.99	0.0001	↓	Taurine and hypotaurine metabolism
7	hypotaurine	3.105	0.94	0.0001	↓
8	N-Acetylneuraminic acid	1.539	0.90	0.0061	↓	Amino sugar and nucleotide sugar metabolism
9	sphinganine	1.365	0.94	0.001	↓	Sphingolipid metabolism
10	testosterone	1.853	0.92	0.012	↓	Steroid degradation
11	Adenine	1.631	0.90	0.0087	↓	Purine metabolism
12	Xanthine	1.304	0.94	0.0003	↑	Purine metabolism
13	Guanine	1.064	0.86	0.0351	↓	Purine metabolism
14	Adenosine diphosphate ribose	3.271	0.93	0.00029	↓	Purine metabolism
15	Cytidine	1.122	0.88	0.0074	↓	Pyrimidine metabolism
16	Adenosine 5′-monophosphate	1.612	0.92	0.0038	↓	Pyrimidine metabolism;Regulation of lipolysis in adipocytes
17	N-Heptanoylhomoserine lactone	1.766	0.97	2.84E-05	↓	Tryptophan metabolism
18	citric acid	1.137	0.86	0.01368	↑	TAC cycle
19	N-Acetyl-L-aspartic acid	2.404	1	0.00017	↑	Alanine, aspartate and glutamate metabolism
20	glycine	1.529	0.75	0.028247109	↑	Glutathione metabolism;porphyrin and chlorophyll metabolism
21	Corticosterone	2.276	0.97	0.00047064	↑	Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion
22	desoxycortone	2.289	1	0.000478393	↑	Aldosterone synthesis and secretion
23	Cholic acid	2.003	0.78	0.037133652	↑	Primary bile acid biosynthesis
24	Prostaglandin G2	1.050	0.93	0.001097557	↑	Platelet activation
25	cinnamaldehyde	1.277	0.94	0.003255697	↑	Inflammatory mediator regulation of TRP channels
26	Arachidonic acid	1.238	0.93	0.001273429	↑	Vascular smooth muscle contraction; Platelet activation; Fc gamma R-mediated phagocytosis
27	4-Pyridoxic acid	1.736	0.93	0.002346317	↑	Vitamin B6 metabolism
28	S-(Formylmethyl)glutathione	1.264	0.79	0.046844413	↑	Metabolism of xenobiotics by cytochrome P450
29	Phenylacetylglycine	3.751	0.99	0.000505711	↑	Phenylalanine metabolism
30	2-Hydroxyphenylacetic acid	1.028	0.90	0.005251903	↑	Phenylalanine metabolism
31	Hippuric acid	1.111	0.96	0.00137572	↑	Phenylalanine metabolism
32	Vanillin	1.133	0.90	0.006734157	↑	Biosynthesis of phenylpropanoids
33	Dehydroascorbic acid	2.697	1	0.001467607	↑	Ascorbate and aldarate metabolism
34	1-methylhistidine	2.670	1	7.60E-09	↑	Histidine metabolism
35	Kynurenic acid	1.397	0.97	0.000120172	↑	Tryptophan metabolism
36	Indole-2-acetic acid	1.452	0.96	0.000375978	↑	Tryptophan metabolism
37	4-Methylphenol	4.432	1	7.72E-05	↑	Nitrotoluene degradation