Table 3.

The significant different metabolites between the HMH and PQ group.

No.	Metabolites	VIP	ROC	P value	Trend	Metabolic pathways
1	N-acetyl-L-aspartic acid	1.77	0.88	0.0498	↑	Alanine, aspartate and glutamate metabolism
2	L-Glutamic acid	1.00	0.86	0.0075	↑	Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Histidine metabolism
3	L-Aspartic acid	1.06	0.87	0.0047	↑	Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Histidine metabolism
4	mesaconic acid	1.62	0.83	0.0113	↑	Pyrimidine metabolism;C5-Branched dibasic acid metabolism
5	Adenosine 5′-monophosphate	2.01	0.77	0.0267	↑	Regulation of lipolysis in adipocytes;Pyrimidine metabolism
6	Methylmalonic acid	1.03	0.94	0.0014	↑	Pyrimidine metabolism;Valine, leucine and isoleucine degradation
7	Cytidine	1.54	0.83	0.0368	↑	Pyrimidine metabolism
8	phosphonoacetic acid	1.25	0.86	0.0115	↑	Microbial metabolism in diverse environments;Phosphonate and phosphinate metabolism
9	Hypotaurine	2.52	0.81	0.0214	↑	Taurine and hypotaurine metabolism
10	L-Glutathione (reduced)	2.87	0.88	0.0025	↑	glutathione metabolism
11	Cysteinylglycine	3.13	0.91	0.0008	↑	glutathione metabolism
12	Succinyl proline	1.22	0.82	0.016	↓	proline metabolism
13	Corticosterone	1.25	0.8	0.0241	↓	Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion
14	Prostaglandin G2	1.5	0.89	0.0033	↓	Platelet activation
15	4-Pyridoxic acid	1.91	0.8	0.0361	↓	Vitamin B6 metabolism
16	citric acid	1.3	0.8	0.0222	↓	TCA cycle; Alanine, aspartate and glutamate metabolism
17	Xanthine	1.68	0.88	0.0062	↓	Biosynthesis of alkaloids derived from histidine and purine;purine metabolism