Fig. 3.

Autoimmune cholangitis was exacerbated in the adoptive transfer and antibody-mediated NK cell depletion model. a-b Splenic CD4⁺ T and CD8⁺ T cells from dnTGFβRII mice were transferred into NK^−/−Rag1^−/− mice or Rag1^−/− mice, and the recipient mice were sacrificed 3–4 weeks later. a Representative H&E staining of liver sections from recipient mice. The black arrows indicate the damaged bile duct. b Scores for liver portal inflammation, bile duct damage and lobular inflammation in NK^−/−Rag1^−/− mice (n = 7) and Rag1^−/− mice (n = 10). c-d An anti-PK136 antibody was intraperitoneally injected into dnTGFβRII mice every two weeks, and the mice were sacrificed 4 weeks later. c Representative depleting effect of the anti-PK136 antibody on liver NK cells. d Representative H&E staining of liver sections from anti-PK136 antibody-treated and control mice