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. 2020 Jan 20;52(1):66–78. doi: 10.1038/s12276-019-0358-4

Fig. 2. Analysis of protein disulfide isomerases (P4HB and PDIA6) in human platelets and plasma between LA+ TE+ patients and control groups.

Fig. 2

a LA+ TE+ patients had significantly increased protein abundance of P4HB in platelets compared to healthy controls (p = 0.005) or patients without a history of TE (p = 0.002). b Standardized abundance of PDIA6 was significantly increased in LA+ TE+ patients compared to healthy controls (p = 0.005) and LA+ TE− patients (p = 0.004). c In addition, P4HB levels in plasma were significantly elevated in LA+ TE+ patients compared to healthy controls (p = ≤ 0.0001). Each dot represents a measurement of a single patient. The patient with CAPS is visualized as a red rhombus. The line between the dots of Fig. 2a, b represents the mean (FDR-corrected t-test) and of Fig. 2c the median (Wilcoxon-Mann-Whitney-U-Test). LA lupus anticoagulant, TE thromboembolism, 2D-DIGE two-dimensional differential in-gel electrophoresis, CAPS catastrophic antiphospholipid antibody syndrome.