. 2020 Feb 4;10:1766. doi: 10.1038/s41598-020-58421-9

Table 2.

k_τ values and ratios for AT₁ angiotensin receptor-mediated arrestin recruitment, diacylglycerol production and calcium mobilization.

Ligand	Arrestin		Diacylglycerol			Calcium
Ligand	k_τ (NFU.min⁻¹)¹	k_τ (% AngII)	k_τ (NFU.min⁻¹)¹	k_τ (% AngII)	Arrestin/DAG k_τ ratio (% AngII ratio)	k_τ (NFU.min⁻¹)¹	k_τ (% AngII)	Arrestin/Ca²⁺k_τ ratio (% AngII ratio)
AngII	0.40 ± 0.03	100	1.7 ± 0.2	100	1.00	2.2 ± 0.2	100	1.0
TRV120055	0.37 ± 0.02	92	2.1 ± 0.1	120	0.74	2.5 ± 0.2	110	0.81
TRV120045	0.38 ± 0.06	93				0.66 ± 0.02	30	3.1
TRV120026	0.25 ± 0.03	62				0.46 ± 0.08	21	3.0
SII	0.20 ± 0.04	49				0.25 ± 0.06	12	4.2

k_τ was measured from the time course data for a maximally-stimulating concentration of ligand (32 μM) as described in Fig. 5 and Supplementary Fig. S6. For k_τ normalized to AngII, the mean k_τ value for the ligand was divided by that for AngII. The k_τ ratio was calculated by dividing k_τ normalized to AngII for arrestin by k_τ normalized to AngII for the pathway (DAG or Ca²⁺) Data are mean ± s.e.m. from three experiments, except for SII in arrestin recruitment (n = 2). ¹ NFU, normalized fluorescence units.