. 2019 Nov 29;122(3):405–412. doi: 10.1038/s41416-019-0654-8

Table 1.

Univariate 5 years of overall survival analysis of TP53 hotspot mutations in HGSOC.

Covariates	Training set (TCGA)				Validation set				Combined data
Covariates	HR	p	q	95% CI	HR	p	q	95% CI	HR	p	q	95% CI
R273 vs Y220	1.16	0.314	0.461	0.87–1.56	1.11	0.482	0.675	0.83–1.48	1.14	0.220	0.372	0.93–1.39
R273 vs S241	1.03	0.715	0.867	0.89–1.19					0.98	0.701	0.907	0.87–1.10
R273 vs G245	1.03	0.749	0.867	0.85–1.24	0.96	0.613	0.693	0.80–1.14	0.99	0.837	0.969	0.87–1.12
R273 vs I195	1.10	0.397	0.546	0.88–1.39					1.11	0.267	0.420	0.92–1.35
R273 vs C176	0.99	0.938	0.977	0.81–1.22					0.99	0.960	0.998	0.85–1.17
R273 vs R175	0.90	0.651	0.842	0.59–1.40	1.16	0.474	0.675	0.77–1.75	0.99	0.998	0.998	0.74–1.35
R273 vs H193	0.95	0.272	0.427	0.86–1.04					0.99	0.570	0.799	0.91–1.05
R273 vs R248	2.86	0.013	0.026	1.25–6.55	1.21	0.652	0.693	0.52–2.81	1.81	0.039	0.072	1.03–3.16
R273 vs C238	1.09	0.125	0.212	0.98–1.23	0.96	0.383	0.670	0.88–1.05	0.99	0.801	0.970	0.93–1.06
R273 vs C275	1.00	0.977	0.977	0.92–1.10	1.02	0.652	0.693	0.94–1.11	1.00	0.951	0.998	0.94––1.07
R273 vs P278	0.99	0.824	0.906	0.87–1.12	1.10	0.189	0.378	0.96–1.25	1.03	0.581	0.799	0.94–1.12
R273 vs Y163C	1.29	0.003	0.009	1.09–1.52					1.25	<0.0001	<0.0001	1.11–1.39
R273 vs G266	1.13	0.006	0.015	1.04–1.24					1.14	<0.0001	<0.0001	1.06–1.22
R273 vs R282	1.10	0.013	0.026	1.02–1.19					1.08	0.007	0.014	1.02–1.15
R273 vs Y163C/G266/R282	5.25	<0.0001	<0.0001	2.18–12.63	4.56	0.005	0.014	1.57–13.21	4.71	<0.0001	<0.0001	2.44–9.10
Group 2 vs Group 1	0.18	<0.0001	<0.0001	0.10–0.34	0.25	0.001	0.004	0.11–0.56	0.21	<0.0001	<0.0001	0.13–0.34
Group 2 vs non-hotspot miss mut	0.29	<0.0001	<0.0001	0.16–0.52	0.36	0.013	0.030	0.16–0.81	0.57	<0.0001	<0.0001	0.45–0.72
Group 2 vs all other mut	0.25	<0.0001	<0.0001	0.14–0.45	0.26	0.001	0.004	0.12–0.57	0.53	<0.0001	<0.0001	0.42–0.66
Group 2 vs truncated	0.24	<0.0001	<0.0001	0.13–0.43	0.26	0.001	0.004	0.12–0.58	0.26	<0.0001	<0.0001	0.16–0.41
Group 2 vs in frame	0.39	0.031	0.057	0.17–0.92					0.26	0.001	0.002	0.11–0.59
Age ≤55 vs >55 years	1.61	<0.0001	<0.0001	1.25–2.08	0.94	0.693	0.693	0.71–1.26	1.31	0.005	0.011	1.09–1.59
Stage I and II vs Stage III and IV	2.70	0.006	0.015	1.34–5.46	2.49	<0.0001	<0.0001	1.51–4.11	2.48	<0.0001	<0.0001	1.64–3.74

miss; missense, mut; mutations, bold indicates statistically significant p values