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Efficacy Measures Stratified by Line of Therapy
| Outcome | Controls (N = 52) | Mut-positive (N = 26) | P-value |
|---|---|---|---|
| Real-world progression free survival by line of therapy (mo) | |||
| First | 7.9 | 21.1 | 0.0046 |
| Second or later | 3.4 | 2.5 | 0.43 |
| Overall response rate by line of therapy—no. with response/no. evaluable (%) | |||
| First | 8/28 (29) | 13/19 (68) | 0.007 |
| Second or later | 0/11 (0) | 1/5 (20) | 0.12 |
A subset analysis to compare ORR and rwPFS by line of therapy in which platinum-based treatment was initiated was performed
