Fig. 3.

The PRC2 cancer mutational landscape. a Missense mutation frequency mapped on the linear structure of PRC2 core components (bin = 5 residues). b Structural mapping of missense mutations of PRC2 genes in cancer. Numbers were obtained from the Catalogue Of Somatic Mutations In Cancer (COSMIC) database¹⁰⁸ and mapped on a composite structural model of PRC2, comprising core components with the addition of JARID2 TR domain and AEBP2 C-terminus (PDB: 5WAI and 6C23). c Missense mutation frequency mapped on the linear structure of PRC2-associated factors (bin = 5 residues)