Table 1.
Domain composition of PRC2 subunits
| Protein | Name | Acronym |
|---|---|---|
| SUZ12 | Zn finger binding domain | ZnB |
| WD-domain binding 1 | WDB1 | |
| C2 domain | C2 | |
| Zn Finger | Zn | |
| WD-domain binding 2 | WDB2 | |
| VRN2-EMF2-FIS2-Su(z)12 box | VEFS | |
| EZH2 | SANT1L-binding domain | SBD |
| EED-binding domain | EBD | |
| β-addition motif | BAM | |
| SET activation loop | SAL | |
| stimulation-responsive motif | SRM | |
| Swi3, Ada2, N-CoR and TFIIIB DNA-binding domain 1 like | SANT1 | |
| Motif connecting SANT1 and SANT2 | MCSS | |
| SANT2-like | SANT2 | |
| CXC domain | CXC | |
| Su(var)3-9, E(z) and Trx domain | SET | |
| Post-SET | Post-SET | |
| EED | WD-repeat region | WD1 |
| WD2 | ||
| WD3 | ||
| WD4 | ||
| WD5 | ||
| WD6 | ||
| WD7 | ||
| PALI1 | Nuclear receptor binding box | NR |
| CTBP binding motifs (x2) | CTBP | |
| G9A interaction region | ||
| Pali interaction with PRC2 domain | PIP | |
| RBBP4 | WD-repeat region | WD1 |
| WD2 | ||
| WD3 | ||
| WD4 | ||
| WD5 | ||
| WD6 | ||
| WD7 | ||
| RBBP7 | WD-repeat region | WD1 |
| WD2 | ||
| WD3 | ||
| WD4 | ||
| WD5 | ||
| WD6 | ||
| WD7 | ||
| PHF1/PCL1 | Tudor domain | Tudor |
| PHD Domain | PHD1 | |
| PHD Domain | PHD2 | |
| Extended Homology domain | EH | |
| Chromo domain | Chromo | |
| MTF2/PCL2 | Tudor domain | Tudor |
| PHD Domain | PHD1 | |
| PHD Domain | PHD2 | |
| Extended Homology domain | EH | |
| Chromo domain | Chromo | |
| PHF19/PCL3 | Tudor domain | Tudor |
| PHD Domain | PHD1 | |
| PHD Domain | PHD2 | |
| Extended Homology domain | EH | |
| Chromo domain | Chromo | |
| EPOP | ELOBC binding box | BC box |
| C-terminal region | CTR | |
| AEBP2 | Zn finger | Zn1 |
| Zn finger | Zn2 | |
| Zn finger | Zn3 | |
| Lysine/Arginine-rich domain | KR | |
| C2 binding domain | C2B | |
| H3K4 displacement domain | H3K4D | |
| JARID2 | Transrepression domain | TR |
| Ezh1/2-binding domain | ||
| Nucleosome interaction domain | ||
| Jumonji N-term | JmjN | |
| AT-rich interaction domain | ARID | |
| Jumonji C-term | JmjC | |
| Zinc finger | ZF |