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. 2020 Feb 4;10:1821. doi: 10.1038/s41598-020-58864-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROR1 inhibition sensitizes BC cells to chemo drugs. (A) Immunoblot assessing efficacy of ROR1 knockdown via siRNA in MDA-MB-231 and SUM159PT. Full length blots are presented in the Supplementary Fig. S8. (B,C) MTT investigating cell viability following Dox/Cis treatment in both cell lines after either siROR1 or Control RNA transfection. (D,E) Fluorescence-based Annexin-V staining assay to assess apoptosis induction in both cell lines after treatment with Dox/Cis and/or StrC. (F) MTT investigating cell viability following Dox/Cis treatment in multidrug-resistant SUM159PT/R after either siROR1 or Control RNA transfection. Statistical analyses via student’s t test. N = 3. *p < 0.05.