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. 2020 Feb 4;10:1821. doi: 10.1038/s41598-020-58864-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROR1 inhibition potentiates DNA damage induced by chemo drugs. (A) Immunofluorescence labelling γH2A.X in MDA-MB-231 transfected with either siROR1 or control RNA then treated with Dox or vehicle control (DMSO). (B) ImageJ quantification of individual γH2A.X foci in nuclei from images obtained in (A). (C) Overall nuclear γH2A.X expression (mean fluorescence intensity), calculated using ImageJ, of cells imaged in (A). Statistical analyses were performed using Student’s t test. *p < 0.05, **p < 0.01.