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. 2020 Feb 4;10:1821. doi: 10.1038/s41598-020-58864-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROR1 promotes ABCB1 stability by repressing UPS degradation via MAPK/ERK. (A) The ROR1/MAPK/ERK/ABCB1 signaling pathway. (B) Immunoblots investigating expression of proteins in the MAPK/ERK pathway after ROR1 knockdown in MDA-MB-231. Full length blots are presented in the Supplementary Figs. S10 and S11 (C) Fluorescence-based assay monitoring activity of the 20 S catalytic subunit of the UPS system which typically degrades ABCB1. Statistical analyses via student’s t test. N = 3. p < 0.05 considered statistically significant.