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. 2020 Feb 4;10:1821. doi: 10.1038/s41598-020-58864-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROR1 promotes ABCB1 transcription by reducing p53/SMARCB1 at ABCB1 promoter. (A) P13K/AKT/p53/SMARCB1 regulation of ABCB1 transcription. (B) Immunoblot investigating global cell p53 levels after ROR1 siRNA knockdown and inhibition with StrC. Full length blots are presented in the Supplementary Figs. S12 and S13. (C) Immunoblots following subcellular fractionation assessing p53 levels in the cytosol and nucleus after ROR1 knockdown. Full length blots are presented in the Supplementary Fig. S14. (D) Luciferase reporter assay monitoring p53 activity in MDA-MB-231 after siROR1 and StrC treatment. (E,F) Chromatin immunoprecipitation assay investigating p53 (E) and SMARCB1 (F) binding to ABCB1 promoter after ROR1 knockdown. All statistical analyses via student’s t test. N = 3. *p < 0.05, ***p < 0.001.