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. 2020 Feb 4;10:1794. doi: 10.1038/s41598-020-58104-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Establishing a stable CRISPR/Cas13 system based on K562 cell line. (a) CRISPR/Cas13 can be used to knockdown mRNA and vlincRNAs in K562. Relative expression level (Y-axis) of the corresponding transcripts in cells co-transfected with plasmids expressing Cas13 and the indicated target gRNA vs those co-transfected with Cas13 and the control Gluc gRNA. (b) Inducible stable Cas13 expression in TRE-LwCas13a-K562 cells. Expression fold change (Y-axis) in response to +Dox treatments compared to the −Dox control. Error bars indicate the SE of three technical repeats.