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. 2020 Feb 4;10:1779. doi: 10.1038/s41598-020-58072-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-21 downregulation via miRzip-21 reduces cancer cell viability in vitro (A) TCGA data showing alteration frequency of miR-21 in various cancer types. (B) RT-PCR analysis showing expression of miR-21 levels in various cancer types. (C) Plot showing relative changes in expression in miR-21 levels in tumor cells as compared to control HEK 293T cells. (D) Schematic representation of the experimental plan for proof-of-principle studies using the LV-miRzip-21. (E-F) RT-PCR showing changes in miR-21 levels post transduction with LVs bearing scramble miR, miRzip-21 or untreated (UT) cells. (E) and quantified in (F). (G) Plot showing viability of different cancer cell lines 72 h post transduction with LVs bearing scramble miR, miRzip-21 or left untreated (UT). Data are presented as mean ± SD. Significant differences between miRzip-21 transduced cells and control groups are indicated by ***(P < 0.001), **(P < 0.01) and *(P < 0.05).