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. 2020 Feb 4;10:1779. doi: 10.1038/s41598-020-58072-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combination of AAV delivered anti-miR-21 and miR-7 prolongs survival of mice bearing patient derived GBM xenografts. (A) Plot showing changes in viability of various GBM cells following combination treatment with AAV-miR-7 and AAV-miRzip-21. (B) Western blot analysis showing changes in various cell proliferation and death markers following treatment with AAV-miR-7 and AAV-miRzip-21. (C) Plot showing changes in tumor volumes of GBM-18-FmC overtime following AAV-miR-7 and AAV- miRzip-21 injections as compared to controls. (D) Kaplan-Meier survival curves following AAV-miR-7 and AAV-miRzip-21 injections as compared to controls. (E) Photomicrographs showing AAV-GFP infection of GBM tumors at day 4 post AAV injection. (F) H&E staining showing changes in tumor burden following a combination treatment of AAV delivered miR-7 and anti-miR-21. Data are presented as mean ± SEM. ***(P < 0.001), **(P < 0.01) and *(P < 0.05). Scale bars represent 100 uM.