Table 1.
Baseline clinical and laboratory characteristics of study participants.
| Characteristic | Value |
|---|---|
| Age (yr) | 23.0 ± 10.4 |
| BSA (m2) | 1.69 ± 0.3 |
| Female, n (%) | 13 (54) |
| Receiving hydroxyurea, n (%) | 19 (79) |
| Baseline Heart rate (bpm) | 74 ± 10 |
| Systolic blood pressure (mmHg) | 118 ± 11 |
| Diastolic blood pressure (mmHg) | 67 ± 8 |
| White blood cell count (103/mm3) | 9.6 ± 3.6 |
| Hemoglobin (g/dL) | 9.9 ± 1.4 |
| Mean corpuscular volume (fL) | 94 ± 19 |
| Reticulocyte count (%) | 8.1 ± 5.2 |
| Platelet count (103/mm3) | 343 ± 98 |
| Bilirubin (mg/dL) | 2.4 ± 1.5 |
| AST (unit/L) | 48 ± 29 |
| LDH (unit/L) | 550 ± 271 |
| Plasma free hemoglobin (mg/dL) | 26 (11–105) |
| Creatinine (mg/dL) | 0.57 ± 0.17 |
| Cystatin C (mg/L) | 0.64 ± 0.13 |
| GFR (mL/min/1.73 m2) | 145 ± 38 |
| NT-proBNP (pg/mL) | 55 (23–150) |
| Native T1 (ms) | 1005 ± 67 |
| ECV | 0.44 ± 0.08 |
| % Predicted maximum oxygen consumption | 57 ± 12 |
| VE/VCO2 slope at maximum exercise | 30 ± 7 |
The values are reported as mean ± standard deviation or median (interquartile range). AST: aspartate aminotransferase, ECV: extracellular volume, GFR: glomerular filtration rate, LDH: lactate dehydrogenase, min: minute, VO2: oxygen consumption, VCO2: carbon dioxide production, yr: year.