Table 2.
Clinical, laboratory, and exercise parameters of study participants based on ECV.
| Characteristic | ECV ≤0.44 (n = 12) | ECV >0.44 (n = 12) | p Value |
|---|---|---|---|
| Age (yr) | 23.0 ± 11.8 | 23.1 ± 9.2 | 0.98 |
| Body surface area (m2) | 1.68 ± 0.33 | 1.61 ± 0.42 | 0.64 |
| Hemoglobin (g/dL) | 10.3 ± 1.5 | 9.4 ± 1.3 | 0.14 |
| Plasma free hemoglobin (mg/dL) | 99 ± 137 | 24 ± 28 | 0.21 |
| Hemoglobin F (%) | 17 ± 13 | 19 ± 13 | 0.73 |
| Heart rate at exercise cessation (BPM) | 174 ± 18 | 162 ± 16 | 0.15 |
| Peak work rate (Watt) | 369 ± 332 | 141 ± 108 | 0.04 |
| Respiratory exchange rate | 1.4 ± 0.1 | 1.3 ± 0.2 | 0.17 |
| VO2 at maximum exercise (mL/kg/min) | 22 ± 2 | 20 ± 2 | 0.47 |
| % predicted VO2 at maximum exercise | 57 ± 13 | 54 ± 10 | 0.39 |
| VE/VCO2 slope at maximum exercise | 30 ± 7 | 32 ± 8 | 0.68 |
| Moderate-to-severe exercise impairment, n (%) | 8/12 (67) | 4/6 (67) | 0.98 |
| VE/VO2 at maximum exercise | 42 ± 11 | 40 ± 6 | 0.65 |
| NT-Pro BNP (pg/mL) | 31 (19–72) | 149 (38–169) | 0.008 |
| FEV1 (%) | 82 ± 12 | 82 ± 18 | 0.98 |
| FVC (%) | 87 ± 13 | 89 ± 14 | 0.76 |
| FEV1/FVC (%) | 93 ± 11 | 92 ± 7 | 0.10 |
ECV: extracellular volume, FEV1: forced expiratory volume in the first second, FVC: forced vital capacity, RLD: Restrictive lung disease, VO2: oxygen consumption, VCO2: carbon dioxide production, Yr: Year.